科(ke)室介紹

教育經(jing)歷(li)

1986年(nian)畢業于(yu)中(zhong)國(guo)人(ren)民(mín)解放軍第四軍醫(yī)大(da)學(xué)獲醫(yī)學(xué)學(xué)士學(xué)位，2003年(nian)赴英國(guo)留學(xué)深造(zao)，2007年(nian)獲英國(guo)阿伯丁大(da)學(xué)腫瘤學(xué)博士學(xué)位，2008年(nian)至2012年(nian)在(zai)美國(guo)加(jia)州大(da)學(xué)戴維(wei)斯分(fēn)校薩克拉們(men)拖醫(yī)療中(zhong)心幹細胞移植中(zhong)心完成(cheng)博士後(hou)工(gong)作(zuò)。

工(gong)作(zuò)經(jing)歷(li)

在(zai)解放軍309醫(yī)院血液腫瘤專(zhuan)業副主(zhu)任醫(yī)師。後(hou)任解放軍309醫(yī)院醫(yī)療科(ke)長(zhang)、醫(yī)務(wu)部(bu)副主(zhu)任等(deng)職務(wu)。2012年(nian)至2017年(nian)在(zai)英國(guo)阿伯丁大(da)學(xué)醫(yī)學(xué)研究院從(cong)事腫瘤耐藥及(ji)轉移機(jī)理(li)的(de)研究。2010年(nian)獲聘北京大(da)學(xué)腫瘤醫(yī)院客座教授(shou)。2017年(nian)在(zai)河北一(yi)洲腫瘤醫(yī)院擔任常務(wu)副院長(zhang)。

診療特長(zhang)

從(cong)事臨牀(chuang)、科(ke)研、醫(yī)院筦(guan)理(li)38年(nian)，積累了(le)豐(feng)富(fu)經(jing)驗(yàn)，對國(guo)內(nei)外腫瘤臨牀(chuang)診療、腫瘤的(de)髮(fa)生(sheng)機(jī)理(li)、腫瘤分(fēn)子(zi)診斷(duan)、耐藥機(jī)理(li)方(fang)面的(de)進(jin)展(zhan)有(yǒu)深入研究，尤爲(wei)擅長(zhang)腫瘤綜郃(he)治療。特别昰(shi)在(zai)腫瘤轉移及(ji)耐藥的(de)機(jī)理(li)研究方(fang)面有(yǒu)較高(gao)的(de)造(zao)詣，對腫瘤的(de)基因特點與預後(hou)的(de)關係(xi)有(yǒu)豐(feng)富(fu)經(jing)驗(yàn)。在(zai)國(guo)內(nei)外學(xué)術(shù)期刊髮(fa)表學(xué)術(shù)論文(wén)30餘篇，其中(zhong)國(guo)外雜志(zhì)24篇。

學(xué)術(shù)論文(wén)

· Lin Cao, Jie Liu, Jin Pu, Gillian Milne, Mei Chen, Heping Xu, Alan Shipley, John V Forrester,  Colin D McCaig, Noemi Lois, Polarized retinal pigment epithelium generates electrical signals that diminish with age and regulate retinal pathology, J Cell Mol Med 2018 Nov;22 (11): 5552-5564

· Cao L, Liu J, Pu J, Collinson JM, Forrester JV, McCaig CD, Endogenous bioelectric currents promote differentiation of the mammalian lens, J Cell Physiol. 2017 Jun 29. doi: 10.1002/jcp.26074. [Epub ahead of print]

· Yang, B., Cao, L., Liu, J., Xu, Y., Milne, G., Chan, W., Heys, SD., McCaig, CD. & Pu, J. (2015). Low expression of chloride channel accessory 1 predicts a poor prognosis in colorectal cancer. Cancer.  2015 May 15; 121(10): 1570–1580.

· Jin Pu, Lin Cao, Colin D McCaig (2015).  Physiological extracellular electrical signals guide and orient the polarity of gut epithelial cells, Tissue Barriers 02/2015; 3(3):e1037417.

· Lin Cao, Colin D McCaig, Jin Pu. Extracellular electric signals regulate neuroblast behaviours in adult brain (2015), Archives of Stem Cells & Research.

· Cao L, Pu J, Scott HR, Ching J, McCaig CD (2015).  Endogenous electrical signals in brain promote chain migration of neuroblasts through up-regulation of the purinergic receptor P2Y1. Stem Cell Rev. 2015 Feb;11(1):75-86.

· Cao L, McCaig CD, Scott HR, Zhao SW, Milne G, Clevers H, Zhao M, Pu J (2014). Polarizing intestinal epithelial cells electrically through Ror2. Journal of Cell Science. 127(Pt 15):3233-9.

· Cao L, Wei D, Reid B, Zhao S, Pu J, Pan T, Yamoah E, Zhao M (2013). Endogenous

electric currents might guide rostral migration of neuroblasts. EMBO Rep 14(2):184-

90. (This paper was highlighted as hot off the press and cover image).

·       Yang B, Cao L*, Liu B, McCaig CD, Pu J (2013). The transition from proliferation to

differentiation in colorectal cancer is regulated by the calcium activated chloride channel A1. PLoS One 8(4):e60861. (*Co-first author).

·       Vu Tran V, Zhang XD, Cao L, Li HQ, Lee BJ, Chen W, Zhao M (2013). Electrically increase transepithelial potentials -- targeting Na+/K+ pumps using synchronized electrical modulation. PLoS One 8(4):e61509.

· Zhao M, Chalmers L, Cao L, Vieira AC, Mannis M, Reid B (2012). Electrical signalling in control of ocular cell behaviors. Prog Retin Eye Res 31(1):65-88.

· Cao L, Graue-Hernandez EO, Tran V, Reid B, Pu J, Mannis MJ, Zhao M (2011).

Down-regulation of PTEN at corneal wound sites accelerates wound healing through increased cell migration. Invest Ophthalmol Vis Sci 52(5): 2272-2278.

· Cao L, Pu J, Zhao M (2011). GSK-3β is essential for physiological electric fields directed Golgi polarization. Cell Mol Life Sci 68(18):3081-93.

·       Vieira AC, Reid B, Cao L, Mannis MJ, Schwab JR, Zhao M (2011). Ionic components of electric current at rat corneal wounds. PLoS One 6(2):e17411.

·       Reid B, Vieira AC, Cao L, Mannis MJ, Schwab IR, Zhao M (2011). Specific ion fluxes generate cornea wound electric currents. Commun Integr Biol 4(4):462-5.

·       Cao L, Zhang XD, Liu X, Chen TY, Zhao M (2010). Chloride channels and transporters in human corneal epithelium. Exp Eye Res 90(6):771-9.

·       Tai G, Reid B, Cao L, Zhao M (2009). Electrotaxis and wound healing: experimental methods to study electric fields as a directional signal for cell migration. Methods

Mol Biol 571:77-97.

·        Pu J, McCaig CD, Cao L, Zhao ZQ, Segall JE, Zhao M (2007). Epidermal growth factor receptor signaling is essential for electric field directed migration of breast cancer cells. J Cell Sci 120(Pt 19):3395-403.

· 解傳(chuan)濱;楊濤;王子(zi)申;方(fang)春鋒;徐壽平;曹林;曲寶林；質(zhi)子(zi)調強放療技(ji)術(shù)與2種光子(zi)旋轉調強放療技(ji)術(shù)在(zai)全中(zhong)樞照射中(zhong)的(de)劑量學(xué)比較，醫(yī)療衛生(sheng)裝(zhuang)備(bei) 2021年(nian)05期

· 方(fang)春峰，候俊，徐壽平，楊濤，曲寶林，曹林，朱龍林，解東，繼達悅；質(zhi)子(zi)治療係(xi)統原理(li)及(ji)其應用(yong)，中(zhong)國(guo)醫(yī)學(xué)裝(zhuang)備(bei)，2021年(nian)4月，第18卷第4期

· 楊濤，曲寶林，徐壽平，解傳(chuan)濱，徐偉，龔璇，曹林；IBA質(zhi)子(zi)筆(bǐ)形束掃描係(xi)統束流性能(néng)驗(yàn)收測(ce)試，中(zhong)華放射腫瘤學(xué)雜志(zhì) 2020-12-15

· 楊濤,徐壽平,解傳(chuan)濱,龔璇,徐偉,曲寶林,王子(zi)申,方(fang)春鋒,曹林；前(qian)列腺癌質(zhi)子(zi)調強與光子(zi)容積旋轉調強放療計(ji)劃質(zhi)量評估[J].中(zhong)華放射醫(yī)學(xué)與防護雜志(zhì),2020,40(1):19-25

· 徐偉;楊濤;解傳(chuan)濱;曲寶林;曹林;王子(zi)申;宋圓圓;方(fang)春鋒;徐壽平;質(zhi)子(zi)點掃描技(ji)術(shù)與光子(zi)Tomotherapy在(zai)前(qian)列腺癌應用(yong)中(zhong)的(de)劑量學(xué)比較，中(zhong)國(guo)醫(yī)學(xué)物(wù)理(li)學(xué)雜志(zhì)2019年(nian) 第10期

科(ke)研課題（國(guo)外）

· Mechanisms of chemoresistance in solid tumours.

· Electrical control of retinal pigment epithelium and PEDF secretion: a new focus for treating age-related macular degeneration,

· The response of astrocytes to extracellular electrical signals (EES): Friend or Foe for CNS wound repair?

· Controlling Brain Tumours Electrically,

· SULSA Postdoctoral Exchange Scheme.

· A functional role for the transepithelial potential difference in cancer metastasis? -----Identification of electrically-regulated metastatic genes in breast cancer,